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Hepatitis delta in patients with resolved hepatitis B virus infection
(European Journal of Gastroenterology & Hepatology, 2018-09)
Background The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals ...
Prevalence and incidence of hepatitis delta in patients with chronic hepatitis B in Spain
(European Journal of Gastroenterology & Hepatology, 2018-09)
Background Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual ...
Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
(Open Forum Infectious Diseases, 2019-02)
Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late ...
HIV co-infection in HTLV-1 carriers in Spain
(Virus Research, 2019-06)
Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. ...
HTLV-1 infection in solid organ transplant donors and recipients in Spain
(BMC Invectious Diseases, 2019-08-09)
Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain
(AIDS, 2019-11-15)
Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all ...
Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains
(Emerging Microbes and Infections, 2020-01-01)
Africa is the largest endemic area for HTLV-1, with many molecular genotypes. We previously demonstrated that some strains from North Africa (a-NA clade) originated from a recombinant event between Senegalese and West ...
Antiretroviral Therapy for HIV-2 Infection in Non-Endemic Regions
(AIDS Reviews, 2020-01)
Human immunodeficiency virus type 2 (HIV-2) was isolated in AIDS patients in 1986. Around 1-2 million people are infected worldwide. The virus is less transmissible than HIV-1, being sexual contacts the most frequent route ...
HTLV-1 infection and health outcomes
(The Lancet Infectious Diseases, 2020-04)
The meta-analysis published by Gill Schierhout and colleagues1 reported an increased relative risk of premature death in individuals infected with HTLV-1 compared with individuals not infected with HTLV-1 (RR 1·57, 95% CI ...
Tough requirements for new antiretroviral drugs
(The Lancet HIV, 2020-03)
Medical and social attention to HIV infection has declined globally and is increasingly focused on developing regions, where the epidemic is still largely uncontrolled. In North America and western Europe, AIDS is rarely ...