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Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades
(AIDS, 2022-02)
Background: The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, ...
Ultra-long-acting antivirals as chemical vaccines to prevent viral diseases
(Future Microbiology, 2022-07)
For two centuries, vaccines have been successful in the fight against viruses, triggering immune protection. Indeed, the elimination of smallpox, the only infectious disease eradicated to date, was made possible through ...
Oral antivirals for the prevention and treatment of SARS-CoV-2 infection
(AIDS Reviews, 2022)
Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-threatening
viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against severe COVID-19 disease
manifestations ...
Pre-Exposure Prophylaxis for viral infections other than HIV
(Infezioni in Medicina, 2022)
The battle against human viral infections has histori-cally relied on two medical strategies, namely vaccines to protect from contagion and antivirals to treat infected patients. In the absence of vaccines, antivirals have ...
Hepatitis C hospitalizations in Spain and impact of new curative antiviral therapies
(Journal of Viral Hepatitis, 2022)
Chronic hepatitis C virus (HCV) infection is major cause of decompensated cirrhosis and liver cancer. The advent of curative new antiviral therapies since year 2015 has dramatically improved the prognosis of HCV patients. ...
Liver cancer and hepatic decompensation events in patients hospitalized with viral hepatitis in Spain
(Hepatology International, 2022)
Background: Chronic viral hepatitis B, C, and D are the main causes of decompensated cirrhosis and liver cancer worldwide. Newborn HBV vaccination was implemented more than 2 decades ago in most EU countries. Furthermore, ...
Late presentation of human T-lymphotropic virus type 1 infection in Spain reflects suboptimal testing strategies: on behalf of the Human T-lymphotropic Virus (HTLV) Spanish Network
(International Journal of Infectious Diseases, 2022)
Objectives: Although only 10% of persons infected with human T-lymphotropic virus type 1 (HTLV-1) may develop virus-associated illnesses over their lifetime, missing the earlier diagnosis of asymptomatic carriers frequently ...
Is SARS-CoV-2 the only cause of long-COVID?
(AIDS Reviews, 2022)
Around 10% of adults infected with SARS-CoV-2 that survive a first episode of COVID-19 appear to experience long-term clinical manifestations. The signs and symptoms of this post-acute COVID-19 syndrome (PACS) include ...
The unexpected high prevalence of HBV subgenotype D4 in patients with chronic hepatitis B in Galicia, a northwestern Spanish region, reflects strong links with Latin America
(Journal of Clinical Virology, 2022)
Background: Hepatitis B virus (HBV) comprises 9 genotypes and multiple subgenotypes that depict differences in geographic distribution, clinical outcome and response to antiviral therapy. However, the molecular epidemiology ...
Envisioning hepatitis delta cure without functional hepatitis B cure
(AIDS reviews, 2022)
[abstract not available]