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A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity

Cabello-Donayre, María; Cabello-Donayre, Irene; Guerra, Diego; Orrego, Lina M.; Morales, Juan C.; Cautain, Bastien; Vicente, Francisca; Pérez-Victoria, José M. (International Journal of Antimicrobial Agents, 2024)

Objectives: New drugs are required to treat neglected diseases caused by trypanosomatid parasites such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi . An Achilles’ heel of these parasites is their heme auxotrophy; ...