• First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine 

      Martinez, Luis; Malaina, Iker; Salcines-Cuevas, David; Teran-Navarro, Héctor; Zeoli, Andrea; Alonso, Santos; De la Fuente, Ildefonso M.; Gonzalez-Lopez, Elena; Ocejo-Vinyals, J. Gonzalo; Gozalo-Marguello, Monica; Calvo-Montes, Jorge; Álvarez-Domínguez, Carmen (Scientific reports, 2022)
      Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the undoubted ...
    • Gold Glyconanoparticles Combined with 91–99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors 

      Terán-Navarro, Hector; Zeoli, Andrea; Salines-Cuevas, David; Marradi, Marco; Montoya, Noemí ; Gonzalez-Lopez, Elena; Ocejo-Vinyals, J. Gonzalo; Dominguez-Esteban, Mario; Gutierrez-Baños, Jose Luis; Campos-Juanatey, Felix; Yañez-Diaz, Sonsoles; Garcia-Castaño, Almudena; Rivera, Fernando; Duran, Ignacio; Álvarez-Domínguez, Carmen (Cancers, 2022)
      This study presents proof of concept assays to validate gold nanoparticles loaded with the bacterial peptide 91–99 of the listeriolysin O toxin (GNP-LLO91–99 nanovaccines) as immunotherapy for bladder tumors. GNP-LLO91–99 ...
    • Testing a vaccine candidate against Hepatitis C virus designed by combinatorial optimization 

      Malaina, Iker; Martinez, Luis; Salcines-Cuevas, David; Teran-Navarro, Héctor; Ocejo-Vinyals, J. Gonzalo; Gonzalez-Lopez, Elena; Soriano, Vicente; Úbeda Cantera, María; Pérez Pinilla, Martin-Blas; Martínez de la Fuente, Ildefonso; Álvarez-Domínguez, Carmen (Scientific Reports, 2023)
      This paper presents a new procedure for vaccine design against highly variable viruses such as Hepatitis C. The procedure uses an optimization algorithm to design vaccines that maximize the coverage of epitopes across ...