Objectives. Professionals in the perfume industry are routinely exposed to numerous chemical substances during olfactory evaluations, some of which may pose inhalation hazards. Existing qualitative risk assessment tools, such as Control of Substances Hazardous to Health (COSHH) Essentials, provide approximate estimates and may not be well suited to industries with highly specific exposure conditions like perfumery. This study evaluates the applicability and limitations of COSHH Essentials in perfume laboratories and proposes an improved qualitative framework tailored to perfumers’ exposure scenarios. Methods. A total of 626 substances from a perfumer’s palette were assessed using COSHH Essentials, which classifies substances into risk levels based on hazard, volatility and quantity. A complementary method incorporating molecular-level hazard analysis, exposure patterns, occupational exposure limits and conservative inhalation dose estimations was developed. Statistical agreement between both methods was examined using Cohen’s κ, and McNemar’s test assessed significant differences. Results. COSHH Essentials identified 76 hazardous substances, while the enhanced method identified 81 substances, including five additional requiring local exhaust ventilation. Agreement was moderate (κ = 0.58; p = 0.031). Conclusion. COSHH Essentials provides a useful baseline but lacks the specificity needed in industries with intentional close-range exposure. The enhanced method enables more precise, context-sensitive assessment and better protection in fragrance laboratories.