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Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase
Álvarez-Domínguez, Carmen (1); Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Tobes, Raquel; García, Isabel; Grijalvo, Santiago; Paradela, Alberto; Seoane, Asunción; Sangari, Felix J.; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino Bernal, I. Concepción; Yañez-Diaz, Sonsoles (Frontiers in Cellular and Infection Microbiology, 10/2020)The glycolytic enzyme and bacterial virulence factor of Listeria monocytogenes, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Lmo2459), ADP-ribosylated the small GTPase, Rab5a, and blocked phagosome maturation. This ... -
Glyceraldehyde-3-phosphate dehydrogenase common peptides of listeria monocytogenes, mycobacterium marinum and streptococcus pneumoniae as universal vaccines
Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Torres-Rodriguez, Paula; Tobes, Raquel; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino-Bernal, Concepción; Yañez-Diaz, Sonsoles; Álvarez-Domínguez, Carmen (1) (Vaccines, 2021)Universal vaccines can be prepared with antigens common to different pathogens. In this regard, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a common virulence factor among pathogenic bacteria of the genera ...